Rationale for mono- versus polytherapy with antiepileptic drugs for patients with epilepsy
نویسندگان
چکیده
منابع مشابه
Adverse effects & drug load of antiepileptic drugs in patients with epilepsy: Monotherapy versus polytherapy
BACKGROUND & OBJECTIVES Although the need for a combination of antiepileptic drugs (AEDs) in the treatment of epilepsy is well justified, but an associated increase in adverse effects (AEs) lends a restriction to polytherapy. The aim of this study was to evaluate AEs and drug load (prescribed daily dose/defined daily doses) of AEDs in patients with epilepsy (PWE). METHODS Consecutive PWEs att...
متن کاملRational Polytherapy with Antiepileptic Drugs
Approximately 30-40% of patients do not achieve seizure control with a single antiepileptic drug (AED). With the advent of multiple AEDs in the past 15 years, rational polytherapy, the goal of finding combinations of AEDs that have favorable characteristics, has become of greater importance. We review the theoretical considerations based on AED mechanism of action, animal models, human studies ...
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Many patients with epilepsy suffer also from coexisting psychological problems. These mental co-morbidities have a significant impact on quality of life of patients with epilepsy. Recent studies have shown that although antiepileptic drugs (AEDs) treat epilepsy, they may increase risk of mental disorders in these patients . Due to the lack of adequate research in this area, we assess...
متن کاملCombining antiepileptic drugs—Rational polytherapy?
The global introduction of 14 new antiepileptic drugs (AEDs) over the past 20 years as adjunctive treatment in refractory epilepsy has triggered an increased interest in optimising combination therapy. With a widening range of available mechanisms of AED action, much activity has been focused on the defining and refining "rational polytherapy" with AEDs that have differing pharmacological prope...
متن کاملPotentially inappropriate antiepileptic drugs for elderly patients with epilepsy.
OBJECTIVES To describe prescribing patterns for older veterans with epilepsy, determine whether disparity exists between these patterns and clinical recommendations, and describe those at greatest risk of receiving potentially inappropriate antiepileptic drugs (AEDs). DESIGN Retrospective administrative database analysis. SETTING All outpatient facilities within the Department of Veterans A...
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ژورنال
عنوان ژورنال: Neurology, Neuropsychiatry, Psychosomatics
سال: 2017
ISSN: 2310-1342,2074-2711
DOI: 10.14412/2074-2711-2017-1s-84-88